5-Pyrimidinamine, 2-chloro- (9CI)
5-Amino-2-chloropyrimidine
CAS: 56621-90-0
Molecular Formula: C4H4ClN3
5-Pyrimidinamine, 2-chloro- (9CI) - Names and Identifiers
| Name | 5-Amino-2-chloropyrimidine |
| Synonyms | 2-CHLOROPYRIMIDIN-5-AMINE 5-amine-2-Chloropyrimidine 5-Amino-2-chloropyrimidine 5-AMINO-2-CHLOROPYRIMIDINE 5-pyrimidinamine, 2-chloro- 5-PYRIMIDINAMINE, 2-CHLORO- 2-Chloro-pyrimidin-5-ylamine 5-Pyrimidinamine, 2-chloro- (9CI) |
| CAS | 56621-90-0 |
| InChI | InChI=1/C4H4ClN3/c5-4-7-1-3(6)2-8-4/h1-2H,6H2 |
5-Pyrimidinamine, 2-chloro- (9CI) - Physico-chemical Properties
| Molecular Formula | C4H4ClN3 |
| Molar Mass | 129.55 |
| Density | 1.437±0.06 g/cm3(Predicted) |
| Melting Point | 198-199℃ |
| Boling Point | 338.8±15.0 °C(Predicted) |
| Appearance | Crystalline Powder or Solid |
| Color | Yellow to brown |
| pKa | -0.08±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.617 |
5-Pyrimidinamine, 2-chloro- (9CI) - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust. |
| HS Code | 29339900 |
5-Pyrimidinamine, 2-chloro- (9CI) - Introduction
5-Amino-2-chroopyrimidine is an organic compound with the chemical formula C4H3ClN2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 5-Amino-2-chloropyrimidine is white crystalline or crystalline powder.
-Solubility: It can be dissolved in water and some organic solvents.
Use:
-Drug synthesis: 5-Amino-2-chroopyrimidine is an important intermediate for many drugs, used in the synthesis of anticancer drugs, antiviral drugs and other pharmaceutical compounds.
-Pesticide synthesis: It can also be used to synthesize certain pesticides.
Preparation Method:
The preparation of 5-Amino-2-chloropyrimidine can be carried out by the following steps:
1. Add thionyl chloride (sulfonyl chloride) to an appropriate solvent, and then slowly add pyrimidine (pyrimidine).
2. The reaction is carried out at an appropriate temperature and reaction time.
3. After completion of the reaction, 5-Amino-2-chloropyrimidine was obtained by appropriate separation and purification steps.
Safety Information:
-5-Amino-2-chlorine is a chemical substance that requires caution when used.
-Because it is an organic compound, it may cause damage to the human body, so avoid inhalation and skin contact.
-Follow safety laboratory procedures when using or handling, and wear appropriate protective gloves and glasses.
-If ingested or in contact with skin, rinse immediately with plenty of water and seek medical advice.
Nature:
-Appearance: 5-Amino-2-chloropyrimidine is white crystalline or crystalline powder.
-Solubility: It can be dissolved in water and some organic solvents.
Use:
-Drug synthesis: 5-Amino-2-chroopyrimidine is an important intermediate for many drugs, used in the synthesis of anticancer drugs, antiviral drugs and other pharmaceutical compounds.
-Pesticide synthesis: It can also be used to synthesize certain pesticides.
Preparation Method:
The preparation of 5-Amino-2-chloropyrimidine can be carried out by the following steps:
1. Add thionyl chloride (sulfonyl chloride) to an appropriate solvent, and then slowly add pyrimidine (pyrimidine).
2. The reaction is carried out at an appropriate temperature and reaction time.
3. After completion of the reaction, 5-Amino-2-chloropyrimidine was obtained by appropriate separation and purification steps.
Safety Information:
-5-Amino-2-chlorine is a chemical substance that requires caution when used.
-Because it is an organic compound, it may cause damage to the human body, so avoid inhalation and skin contact.
-Follow safety laboratory procedures when using or handling, and wear appropriate protective gloves and glasses.
-If ingested or in contact with skin, rinse immediately with plenty of water and seek medical advice.
Last Update：2024-04-09 21:04:16
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CAS: 56621-90-0
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QQ: 3008007409
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CAS: 56621-90-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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